Trainer Donald McCain hopes Weird Al can yield an even better result than his third-placed finish in the Betfair Chase at Haydock last season.
The nine-year-old appears to run his best races after a break, as he showed when winning last year's Charlie Hall, a race he missed this season.
"We didn't feel he was quite ready to go to the Charlie Hall so we went straight to the Betfair," said McCain.
"He ran a nice race in it last year on his second run back. He probably wasn't as sharp as he was, so we've concentrated on going there fresh this time.
"He seems in great nick at the moment and after this I don't quite know where we'll go, but we'll probably aim him more at Aintree as a Grand National horse than at the Gold Cup."
Cannington Brook has a mountain to climb on official ratings, but is two from two at Haydock and loves heavy ground.
Trainer Colin Tizzard said: "He is 30lb wrong with the others but he loves heavy ground and is unbeaten around Haydock.
"I hope there is a bit more improvement to come from him as he needs to improve 20lb to place on Saturday, but the ground will help him."
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