John Smith's is to end its sponsorship of the Grand National after the 2013 renewal of the race.
The beer producer has leant its support to the National since 2005 and told the Times it was a "difficult" decision to end its sponsorship of the three-day April meeting.
John Smith's spokesman David Jones said: "We will continue to be involved with the sport at other courses, including York, Newcastle and Brighton.
"The Grand National has been one of the jewels in our sponsorship crown and this decision was difficult. We will be exploring ways in which John Smith's can continue to be involved in the three-day meeting and talks with Aintree will take place in the coming months."
Aintree chairman Lord Daresbury is confident the meeting will not be short of suitors.
He said: "I'm sad about it. With a new management team in place, it comes at a bad time and puts more pressure on us all. It would naturally have been easier if John Smith's had been willing to extend the contract again, but I am completely confident the race will attract plenty of new interest.
"I genuinely believe it is a commercial decision. The image of the race has patently been a consideration, though I'm sure it was not the overriding one. I'm sure they got tremendous value out of the sponsorship and the branding exposure at the course was unprecedented."
John Smith's brand manager Karen Crowley said it was "the right time to move on" after a nine-year association with the National meeting.
She said: "We end our long association in the knowledge we have created a successful and significant sponsorship model that will serve Aintree and its new sponsors well in the future.
"We've enjoyed nine exciting years as the title sponsor of jump racing's flagship event, during which time we have seen the John Smith's Grand National achieve record TV viewing figures and attendances. However, we felt that now was the right time to move on, reflecting changes in the ale market and the development of the John Smith's brand."
10 December 2013BHA's Brickell at corruption summit
Hills has Smart purring
McCoy praise for retired Binocular
St Nick continues recovery fight
Big guns remain in Navan feature
New course key for Attaglance
Diakali team consider Relkeel run
Ruby given chase entry
Binocular bows out
Rock team plan positive tactics
Gold fails to sparkle
Star pair head International list
Regal takes Hexham test
Thyestes aim for Cootamundra
Walsh sweet on Arvika switch
Walters to present McNamara cheque
Aintree aim for Busy
Grand National aim for Your Busy
Walters to present McNamara cheque
Four-star Harley at Wolverhampton
Jacob all set for Al Ferof
Sprinter prospect exciting Kempton
Winner a Strongpoint for Crawford
Hurricane honoured in HRI awards
Ground key to Topper plans
African chasing Uttoxeter spoils
Prince set for Cheltenham Gold run
Betfair goal for Trouble
9 December 2013Drowne waits on X-ray news
Swan delighted with Changer
Wolverhampton to replace surface
Russell aims for Thursday return
Bright start for New Dawn
Twin lights up Hilly Way
Durkan stroll for Arvika
Unioniste has Lexus aim
New One heading to International
Drowne in hospital after fall
Baby in running for Warwick
Moore sets sights on Kempton
Cloud and Lantern sunk in Mile
8 December 2013Twin lights up Hilly Way
Ex-Oxx ace Mofeed lifts Cup
Kanaloa sizzles in Sprint
Dominant shocks The Fugue in Vase
Turner back in business
Faugheen in impressive strike
Flemenstar out of John Durkan
Unioniste claims Listed prize
Grugy great in Tingle Creek
V for victory for Henderson
Chance best in Becher thriller
Hinterland reigns in Henry VIII
Mullins strikes with Gitane
7 December 2013V for victory for Henderson
Twinlight out to show the Way
Wyck primed for big Aintree run
Dandino and Rock miss Vase run
Bec puzzler for Lavelle
Moore's Vino is vintage stuff
Mullins sets sights on Navan
Captain taking charge for Henderson
George plots Aintree gold rush
King out to reign in Henry VIII
Newcastle in talks over AW track
Sir champing at bit for Durkan date
Baby on board for Becher