John Smith's is to end its sponsorship of the Grand National after the 2013 renewal of the race.
The beer producer has leant its support to the National since 2005 and told the Times it was a "difficult" decision to end its sponsorship of the three-day April meeting.
John Smith's spokesman David Jones said: "We will continue to be involved with the sport at other courses, including York, Newcastle and Brighton.
"The Grand National has been one of the jewels in our sponsorship crown and this decision was difficult. We will be exploring ways in which John Smith's can continue to be involved in the three-day meeting and talks with Aintree will take place in the coming months."
Aintree chairman Lord Daresbury is confident the meeting will not be short of suitors.
He said: "I'm sad about it. With a new management team in place, it comes at a bad time and puts more pressure on us all. It would naturally have been easier if John Smith's had been willing to extend the contract again, but I am completely confident the race will attract plenty of new interest.
"I genuinely believe it is a commercial decision. The image of the race has patently been a consideration, though I'm sure it was not the overriding one. I'm sure they got tremendous value out of the sponsorship and the branding exposure at the course was unprecedented."
John Smith's brand manager Karen Crowley said it was "the right time to move on" after a nine-year association with the National meeting.
She said: "We end our long association in the knowledge we have created a successful and significant sponsorship model that will serve Aintree and its new sponsors well in the future.
"We've enjoyed nine exciting years as the title sponsor of jump racing's flagship event, during which time we have seen the John Smith's Grand National achieve record TV viewing figures and attendances. However, we felt that now was the right time to move on, reflecting changes in the ale market and the development of the John Smith's brand."
14 February 2016Gary Moore keen to answer Ar Mad question at Plumpton
Danny Mullins aiming to be fit for Cheltenham
Nick Williams at a loss to explain lack of outside rides for Lizzie Kelly
No Haydock outing for The Druids Nephew
Dan Skelton keeping faith with Three Musketeers
Nicky Henderson left scratching his head after L'Ami Serge defeat
Take Cover in line for Lingfield return
Catterick forced to inspect
Ed de Giles favours Fred Winter for Akavit
No jumping at Lingfield on Tuesday
Green light for Exeter
Lizzie Kelly has eye for the big time as Agrapart takes Newbury prize
Sempre Medici strikes under Ruby Walsh to take Gowran honours
Dodging Bullets gunned down by Top Gamble at Newbury
L'Ami Serge floored at Warwick by Violet Dancer
Houblon Des Obeaux dominates Denman Chase at Newbury
Smashing effort gives Henry de Bromhead Gowran glory
Open Eagle soars at Warwick for Willie Mullins
Dan Skelton looks to Aintree with Newbury winner Meet The Legend
Jessica Harrington expects Ttebbob to show true colours in Flyingbolt at Navan
13 February 2016Count Guido Deiro outstays his rivals
Ben Pauling thrilled with Barters Hill as Cheltenham Festival looms large
Black Hercules set to star in Ten Up at Navan
Tuesday's Lingfield card subject to Sunday inspection
Nicky Henderson's Buveur D'Air looks to book Supreme place at Exeter
Jonjo O'Neill has high hopes for Taquin Du Seuil on Warwick return
Josses Hill peaks at Kempton for red-hot Nico de Boinville
Willie Mullins seeking more Gowran gains with Sempre Medici
Nicky Henderson joy at 'perfect' My Tent Or Yours Kempton workout
Open Eagle seeking to book Cheltenham ticket at Warwick
Tony Martin and Dedigout target Boyne brace at Navan
Paul Nicholls hoping Dodging Bullets can fire in Newbury return
Rocky Creek aiming to regain winning thread as he tackles Denman date at Newbury
L'Ami Serge aiming to book Arkle ticket in Kingmaker test at Warwick
Connections hoping Blazer is tailor-made for Betfair test
12 February 2016Kempton scorer Josses Hill back in business for Nicky Henderson
Victoria Pendleton to gain more point-to-point experience
Morning chasing Red Mills glory at Gowran
Willie Mullins seeking more Gowran gains with Sempre Medici
Harry Bentley joins Roger Varian's Newmarket team
Oisin Murphy sidelined by broken collar bone
Martin Lane sidelined following Kempton fall
My Tent Or Yours to have Kingwell prep at Kempton
Top Notch handed Morebattle Kelso aim
Exeter call precautionary check for Sunday card
Market Rally repels British raiders to claim UAE Guineas gold at Meydan
Ma Du Fou strikes Listed gold for Warren Greatrex at Huntingdon
David Pipe mulling Festival hurdles switch with Kings Palace
Winter Escape on Aintree trail following Doncaster victory for Alan King
National aims for Kerry Lee's trio of star staying chasers
Nico de Boinville keen on Altior Cheltenham chance
Willie Mullins considering Punchestown test for Annie Power
Tom George issues ground warning ahead of God's Own Kempton spin
Jonjo O'Neill swerves Newbury with More Of That
11 February 2016Bangor and Uttoxeter beaten by weather
Mags Mullins sets sights on Cheltenham Festival with Thurles winner Ballychorus
Ma Du Fou cashes in with Banks success at Huntingdon
Tom George earmarks Doncaster prep for Grand National hope Saint Are
Willie Mullins set to chart direct Cheltenham route with Annie Power
Tracey Collins joy at Captain comeback at Dundalk
Blazer features in five-pronged Willie Mullins Newbury raid
Uttoxeter makes early call to abandon Saturday fixture
Ruby Walsh left deflated by Killultagh Vic injury
Bangor Friday card declared a washout
JLT favourite Killultagh Vic ruled out of Cheltenham Festival
Weekend workout planned ahead of Ascot 'option' for Flemenstar
Triumph Hurdle contender Fixe Le Kap heading for Victor Ludorum at Haydock
Kim Bailey has Supreme thoughts for Charbel
North Hill Harvey bids to secure Cheltenham ticket at Huntingdon
Gigginstown happy to play waiting game in Cheltenham Gold Cup
Peace And Co undergoes 'straightforward' respiratory procedure
Victoria Pendleton poised for hunter chase bow at Fakenham
Paul Nicholls flat out to prove Aux Ptits Soins Cheltenham fitness