Paul Nicholls will be seeking a fourth success in the Betfred Becher Chase at Aintree in the last 10 years as he saddles Join Together.
The seven-year-old was third in the Mildmay Novices' Chase at the track in April and was down the field on his return at Ascot last month.
Nicholls said: "Join Together is in good form. I was a bit disappointed with him at Ascot but hopefully with different fences and a different day, he will do better. I don't think he is particularly well handicapped but he will probably be suited by the fences and, if he is, I will give him an entry in the National."
David Pipe saddles two runners, with Swing Bill and Problema Tic flying the flag for Pond House.
Swing Bill was a winner at Cheltenham last time and finished 10th in the National last season, while Problema Tic was fifth in a Grade Three event at Prestbury Park on his return.
"Swing Bill ran in the race last year (when pulled up) and is not getting any younger. But he ran in the National and seems to like Aintree, although I wouldn't want the ground too soft for him," said Pipe.
"Problema Tic is another who does not want conditions too soft. I was pleased with him at Cheltenham on his comeback."
Big Fella Thanks will be having just his second start for Tom George as he has another crack at the National fences. The 10-year-old was fourth in the 2010 Grand National when trained by Nicholls and seventh a year later when handled by Ferdy Murphy.
He was off the track after that outing until unseating Paddy Brennan in a veterans' chase on the Mildmay course.
George said: "It didn't quite go to plan last time, but maybe that was to our benefit as he is still off the same handicap mark. He's been round there a few times now so he can certainly jump the fences, but I don't think he quite gets home over the National trip. Three miles two furlongs will probably suit him better."
30 October 2014Hawk given Greatwood option
Royal summons for Apache
Hannon: Early speed key for Osaila
Bowe takes aim at WKD bullseye
Hootenanny 'smoking' for BC mission
Avenue roads lead to Newmarket
Shu to be kept busy
Scu sweet on Sensation Ascot raid
Murtagh succumbs to Cup charms
Dandino to stay in Australia
Glance denied Mackinnon defence
Bailey ace rules Supreme at Taunton
O'Brien hit by Magician blow
Diablo in big-race picture
Buckley raises Toast to Osborne
Pastille seeking four-timer
Conti all set for Charlie Hall
Barnes out to storm Saint-Cloud
Williams issues Buywise warning
Lynam reveals Slade stalls fears
29 October 2014Lame Magician out of Breeders' Cup
Diablo in big-race picture
Mullins enters strong Hennessy team
Damaged hock behind Estid reverse
Eckhart team rocked by injury blow
Hunt Ball makes Power play
Morgiana a T bone of contention
Kirby ponders Buttons French raid
Glance camp turn to Williams
Wohler trusts 'professional' Moore
Red alert to Cup challenge
Head targets more Mile glory
Mile hope Toronado in 'great form'
Telescope camp banking on Moore
Twiston-Davies link excites Moore
Flying third to Bob on hurdling bow
Harden to test top staying waters
Godolphin take share in Belardo
Mullins has big guns at Down Royal
Annacotty set for Kempton return
Powell and Bradley cleared
28 October 2014Fingal camp on weather watch
More injury woe for Popham
Dickin unveils Thomas gameplan
Power stalls in Flemington spin
Toast drawn nine in BC Classic
My Ambivalent passed fit by vets
Harry out to bring House down
Three and easy for ton-up Hanagan
Wood carves out Galway verdict
More Of That in Wetherby frame
Big guns confirmed for Charlie Hall
Byron pencilled in for Far East
Newbury reverts to original title
Magician to stay in the US
Henderson considers hurdles for Bob
27 October 2014Mountainous back on National trail
Ground to dictate Gold run
Elite aim for Rendezvous
Classic dreams at Leopardstown
Smullen celebrates seventh title
Cheltenham target for Module
Pete shows his Aintree mettle
Royal-Oak double for Boistron
Starchitect in surprise strike
New One given Haydock mission
Balding excited by Park prospects
Sights set high for Crafty