Paul Nicholls will be seeking a fourth success in the Betfred Becher Chase at Aintree in the last 10 years as he saddles Join Together.
The seven-year-old was third in the Mildmay Novices' Chase at the track in April and was down the field on his return at Ascot last month.
Nicholls said: "Join Together is in good form. I was a bit disappointed with him at Ascot but hopefully with different fences and a different day, he will do better. I don't think he is particularly well handicapped but he will probably be suited by the fences and, if he is, I will give him an entry in the National."
David Pipe saddles two runners, with Swing Bill and Problema Tic flying the flag for Pond House.
Swing Bill was a winner at Cheltenham last time and finished 10th in the National last season, while Problema Tic was fifth in a Grade Three event at Prestbury Park on his return.
"Swing Bill ran in the race last year (when pulled up) and is not getting any younger. But he ran in the National and seems to like Aintree, although I wouldn't want the ground too soft for him," said Pipe.
"Problema Tic is another who does not want conditions too soft. I was pleased with him at Cheltenham on his comeback."
Big Fella Thanks will be having just his second start for Tom George as he has another crack at the National fences. The 10-year-old was fourth in the 2010 Grand National when trained by Nicholls and seventh a year later when handled by Ferdy Murphy.
He was off the track after that outing until unseating Paddy Brennan in a veterans' chase on the Mildmay course.
George said: "It didn't quite go to plan last time, but maybe that was to our benefit as he is still off the same handicap mark. He's been round there a few times now so he can certainly jump the fences, but I don't think he quite gets home over the National trip. Three miles two furlongs will probably suit him better."
9 March 2014Cheltenham team monitor ground
Fenton delays Instalment call
Activial to duck Triumph mission
Hope springs eternal for Encore
Avenue roads lead to Irish Oaks
Fab Fly takes on eight in Champion
Dude's the main man
Top trainers reject watering
Hinterland takes Champion test
Baltimore sets up bonus bid
Warrior wins Trial battle
Fallon hits Meydan heights
Chartreux bounces back to best
Brave Vic has Final word
Soumillon strikes on super Shea
On His Own joins Gold Cup field
8 March 2014Queally hits Sandown target
Briar tops Bartlett contenders
Calipto leads Triumph hopefuls
Ginge fires burn brightly for Neild
Creek forced out of Gold Cup
Milan targeting Final glory
McCoy to miss Sunday and Monday
Exchange rate pays dividend
Temps doubtful for Festival
Conor settles in at Cheltenham
De Bromhead sweet on Special
Epsom to honour St Nick
Mullins dominates JLT entries
Al and Dynaste top Ryanair field
Big two lead World possibles
7 March 2014Lockinge target for Tonto
All set for a super Saturday
Silver aiming to shine
Imperial only thought for Honeyball
Distance fears for Highland
Montiridge preps for Dubai trip
Ayr gets go-ahead
Ayr delay inspection decision
Benbulben misses Cheltenham
Card 'gut wrencher' for Tizzard
Guard stands tall for new record
Faugheen looms over Neptune field
Ballycasey stands firm in RSA
Sire spearheads Queen Mother list
Australia still in Derby shake-up
Henderson perfectly happy with Tent
Regal leads the way in Imperial
6 March 2014McNamara in 'excellent spirits'
Codd snapped up for Sea
Farm National bid in the balance
Byron all set for Aussie challenge
Ayr takes precautions
Bridgwater salutes unsung hero
Murtagh watches on at Lingfield
Mullins retains Fly supporting cast
Bittar welcomes bill amendments
Fenton cleared for Festival runners
Trip concerns sway McCoy to Fishers
Regal vies for Imperial rule
Mullins quintet in Supreme mix
Arkle has Champagne sparkle
Rizeena given dual Guineas options