Sprinter Sacre is one of just 17 entries in the Sportingbet Queen Mother Champion Chase at Cheltenham on March 13.
Nicky Henderson's giant was an easy winner of the Arkle last March and will attempt to follow in the footsteps of Sizing Europe who landed the two races in successive seasons.
Henderson has also entered last year's winner Finian's Rainbow, who has only been seen once this season when disappointing at Ascot, and the exciting Simonsig, who is currently a red-hot favourite for the Arkle.
Sizing Europe again has the option of reclaiming his crown but he has also been entered in the Gold Cup and the Ryanair Chase.
His trainer Henry De Bromhead said: "The Champion Chase is a race we are looking at for Sizing Europe. He has been entered in the Ryanair and the Gold Cup too and we just want to keep our options open at this stage.
"He seems in great form at the moment and we have been delighted with his performances this season. His win at Clonmel was very impressive. I'd imagine he will have one more race before the Festival and we are looking at the Tied Cottage Chase at Punchestown in early February."
Last year's Arkle runner-up Cue Card, the extremely talented Flemenstar, Sanctuaire, William's Wishes and Rubi Light are also in the mix.
The sponsors make Sprinter Sacre their 4-9 favourite but they have not quoted a price for Simonsig.
Queen Mother Champion Chase, sponsors bet: 4-9 Sprinter Sacre, 9-2 Flemenstar, 7-1 Sizing Europe, 9-1 Finian's Rainbow, 10-1 Sanctuaire, 14-1 Cue Card, 25-1 Rubi Light, Somersby, Williams Wishes, 33-1 bar.
26 November 2014Staying aims for Trev
Retirement for National hero Mania
Fenton lodges ban appeal
Knott found in breach of rules
No stopping Twiston-Davies
Bans for jockeys in flag drama
Djak experience a concern for Walsh
More headlines Long Distance field
Tributes flow for Lady Herries
McCoy returns at Fontwell
25 November 2014Void race drama at Sedgefield
Colombieres stars in Mullins entry
Bridgwater buoyed by Bolster
Trade ready to storm Hong Kong
Bowe ponders Robin Power play
Apache on the march for Drinmore
Pipe - Stamina key to Bally chance
Sacre not guaranteed for Sandown
Tower 'sore' after Navan spill
Spirit ensures more Henderson woe
Walsh praise for Vautour
Walsh cool on Faugheen odds
Victory team on weather watch
New relief for Twiston-Davies
Nicholls planning dual George raid
Leather in fine form ahead of Cup
24 November 2014Hobbs upbeat about Fingal raid
Fry keen for crack at Tolworth
Midnight to stay over hurdles
Creek seeking Hennessy Gold
Dynaste team consider George run
Topper target hinges on ground
Followme poised for Drinmore date
Balbriggan lands Troytown gamble
Vautour impresses on chasing debut
Un De Sceaux set for Thurles
Melodic team face tough choice
Henderson aims at Listed prize
Croco in frame for Topham
Deputy in Kempton firing line
McBratney banks on Boy progress
23 November 2014Balbriggan all the way
Vautour off to impressive start
Belle set for hurdling campaign
Silvi scraps to Betfair glory
Bally sparkles on Mullins' big day
Kelly's a Fixed Brush hero
Faugheen turns on the style
Fenton banned for three years
Amlin double for fab Ferof
New One excels in Haydock romp
Flyer grounds Ascot rivals
Vasco a cut above opposition