Sprinter Sacre is one of just 17 entries in the Sportingbet Queen Mother Champion Chase at Cheltenham on March 13.
Nicky Henderson's giant was an easy winner of the Arkle last March and will attempt to follow in the footsteps of Sizing Europe who landed the two races in successive seasons.
Henderson has also entered last year's winner Finian's Rainbow, who has only been seen once this season when disappointing at Ascot, and the exciting Simonsig, who is currently a red-hot favourite for the Arkle.
Sizing Europe again has the option of reclaiming his crown but he has also been entered in the Gold Cup and the Ryanair Chase.
His trainer Henry De Bromhead said: "The Champion Chase is a race we are looking at for Sizing Europe. He has been entered in the Ryanair and the Gold Cup too and we just want to keep our options open at this stage.
"He seems in great form at the moment and we have been delighted with his performances this season. His win at Clonmel was very impressive. I'd imagine he will have one more race before the Festival and we are looking at the Tied Cottage Chase at Punchestown in early February."
Last year's Arkle runner-up Cue Card, the extremely talented Flemenstar, Sanctuaire, William's Wishes and Rubi Light are also in the mix.
The sponsors make Sprinter Sacre their 4-9 favourite but they have not quoted a price for Simonsig.
Queen Mother Champion Chase, sponsors bet: 4-9 Sprinter Sacre, 9-2 Flemenstar, 7-1 Sizing Europe, 9-1 Finian's Rainbow, 10-1 Sanctuaire, 14-1 Cue Card, 25-1 Rubi Light, Somersby, Williams Wishes, 33-1 bar.
2 September 2014ARC "committed" to Newcastle plan
Panther primed for Leger mission
Noble on Champion Mission
Danzeno to enter big league
Story set for Dubai return
Ruler in line for Foy return
BHA turn down Newcastle bid
Towcester not "turning its back"
Demuro booked for Moon Arc prep
Chicquita nears return
Murphy excited by Purse
Surprise Matron aim for Tapestry
Maguire nearing racecourse return
Estimate among bumper Cup entry
Maguire hails 'fantastic' Peddlers
Balding staying grounded with Park
Culloty joins Leger Legends
Regard among September possibles
Cox takes Haydock plunge with Love
Paddy gunning for Chepstow
Athenian has sales date
No hurry for Cape call
Mirza on Abbaye trail
1 September 2014McCain salutes retiring Peddlers
Seven Towcester meetings go to ARC
Further checks for Condon
Due set to miss Sprint date
Condon 'stable' after Cork fall
Queen rules supreme for Smith
River eases to debut success
Carla tops it up to four
Atzeni strikes on Cappella
Ocean team want Haydock rain
Big time beckons for Orange
Palmer aims high with Aktabantay
Hills ponders Dutch gameplan
31 August 2014Atzeni strikes on Cappella
Imminent return Likely
Logic on comeback trail
Dan edges closer to Mile high
Keane error costly for Unrequited
Notarfbad makes all in Mildmay
Orange enjoys Big win
Fabre strikes with Fintry
Akta in late Solario swoop
Icon takes starring role
Pearl fires home in Bullet
Shortall suffers injury setback
Tent team consider chasing
30 August 2014Keane error costly for Unrequited
Shepherd's sent to Tower
Time will tell for Charlton
Stack filly Alive to chance
Sansevero sent to Tower
Palmer plots Solario success
Fabre has high hopes for Fintry
Belardo team keen on Champagne
Rigueur targets Chester consolation
Native in hunt for Bullet gains
Arc still target for Taghrooda