Connections of Captain Americo have targeted the Betfred Eider Chase at Newcastle ever since he finished second in the Borders National at Kelso in December.
Third in last year's Eider, his trainer James Ewart is hoping for another solid performance.
"He's in good form and we're very happy with him. This race has been the plan since he ran in the Borders National," said the Langholm handler.
"He doesn't run well back to back quickly. He needs large gaps between his races and this seemed a sensible opportunity."
Tom George took Desperate Dex out of the race at the final declaration stage but will be represented by Monsieur Cadou. The eight-year-old has not run since winning at Haydock in November, but that does not worry the Slad trainer.
"We were really pleased with his last run at Haydock and we've sat tight with him since then. This race has been the plan for a while," said George.
"The way he was staying on at Haydock suggests the trip will suit him well and he does seem to have found improvement since tackling extreme distances. He's 7lb out of the handicap, but the jockey takes off 7lb. The ground shouldn't be a problem for him and we're looking forward to it."
Mortimers Cross defeated Captain Americo when winning the Borders National and his owner/trainer John Needham has his fingers crossed the 12-year-old can put behind him a disappointing run at Ffos Las on Boxing Day.
The Ludlow handler said: "We're hoping he runs well. He seems fine and he's not been out since Boxing Day, when he was disappointing. It may have been the ground, or perhaps that run came too soon after Kelso.
"We are keeping our fingers crossed and Andrew Thornton, who rode him at Fontwell, said we should run him in the Eider. We are doing that and Andrew is on him, so we are hoping for the best."
5 July 2015'Diamond' Ainippe delights Lyons
Another German Derby for Schiergen
No luck for Geraghty on return
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Arc considered for Horn swansong
Tonto earmarked for York date
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Kurland set for Newmarket return
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Eye sees off Marathon rivals
Blond shows her true colours
Notarised lands Newton prize
Basem proves up to Challenge
Tiana takes Oaks triumph
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Cymro claims Haydock honours
Maria added to Falmouth field
4 July 2015Horn calls the tune in Eclipse
Tiana takes Oaks triumph
Flash fires home
Majestic vies for Fairyhouse rule
Geraghty back in business
Walsh indebted to king Kauto
Angel confirmed Sandown non-runner
Doyle and Johnston shine at Sandown
Johnson scorches to fastest fifty
Windshear up for the Cup
Muhaarar in great form - Hills
Chantilly off the radar for Test
Gatsby sets sights on Horn
Queen aiming to reign in Oaks
Gosden respects Golden rivals
3 July 2015Cyclone set for Leopardstown outing
Waady aiming to step up
Angel major Sandown doubt
Strong Gosden hand at Newmarket
Doyle up for the Challenge
Sandown team mull watering plans
Kazeem on comeback trail
Lennox option for Limato
Magnificent seven for Elliott
Pendleton thrilled with first ride
Balding hoping for Park August run
Kirby unscathed in house fire
Pilot charters path to York
Provenance has claims on Sandown
Soapy out to slay Dragon rivals
Spencer rides Gatsby in Eclipse
Space considered for Ascot return
2 July 2015Creighton discharged from hospital
Postulation checks in at Belmont
Charming thoughts turn to Doncaster
Deauville date for Diamond
Mecca's takes Thirsk honours
Dods waits on Angel decision
Soumillon takes Certain ride
Mile on Spear radar
September aim for Tryster
Cup aim for Arab
Time out for Hannon aces
Close encounter excites Doyle
Island to drop in grade